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KMID : 1007520150240010307
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.307 ~ p.314
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Anti-hyperglycemic and Hypolipidemic Effects of Baechukimchi with Ecklonia cava in Type 2 Diabetic db/db Mice
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Lee Hyun-Ah
Park Mi-Hwa
Song Yeong-Ok
Jang Mi-Soon
Han Ji-Sook
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Abstract
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Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava were investigated in type 2 diabetic db/db mice. Baechukimchi with 15% added E. cava (BKE) was fermented at 5oC for 28 days to obtain optimally ripened BKE (pH 4.28, acidity 0.71). BKE was subjected to extraction using 80% methanol. Male db/db mice were divided into groups of db/db-control, db/db- BKE, and db/db-rosiglitazone (db/db-RG). Compounds were orally administered every day for 6 weeks. The db/ db-BKE mice had lowered blood glucose and plasma insulin levels. Plasma total cholesterol, triglyceride, and LDL-cholesterol levels in db/db-BKE mice were significantly (p<0.05) decreased, compared with untreated db/db mice, while db/db-BKE mice had significantly (p<0.05) increased HDL-cholesterol levels. The db/db- BKE mice had significantly (p<0.05) decreased levels of liver total cholesterol and triglyceride. BKE significantly (p<0.05) increased antioxidant enzyme activities, and ROS and lipid peroxidation levels were significantly (p<0.05) lower in db/db-BKE mice than in db/db mice.
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KEYWORD
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Ecklonia cava, baechukimchi, C57BLKS/J-db/ db mice, antihyperglycemia, hypolipidemia
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